Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed Forearm Crutches death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related adverse events, including arthralg
Diagnosis of pelvic gastrointestinal stromal tumors (GISTs) can be challenging because of their nonspecific presentation and similarity to gynecological neoplasms.In this series, we describe the clinicopathological features of 20 GIST cases: 18 patients presented with pelvic mass Sailing Long Johns and/or abdominal pain concerning gynecological dis
Pollen, the male gametophyte of seed plants, is extremely sensitive to UV light, which may prevent fertilization.As a result, strategies to improve plant resistance to solar ultraviolet (UV) radiation are required.The tardigrade damage suppressor protein (Dsup) is a putative DNA-binding protein that enables tardigrades to tolerate harsh environment
Abstract Malaria is still a devastating Gas Cooker disease with 228 million cases globally and 405,000 lethal outcomes in 2018, mainly in children under five years of age.The threat of emerging malaria strains resistant to currently available drugs has made the search for novel drug targets compelling.The process by which Plasmodium falciparum para